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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) of more than 27, provided they also have problems with weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of 4.1% rather than participants who were given placebos) throughout a 12- month period, while a different study involving patients with type 2 diabetes had an average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to lose weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err along the side of caution and allow the FDA do its job and demand some study be done so that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to generate income and that they would say anything to keep people on the medications.

    Researchers discovered that participants using this drug for any year, lost excess weight within four weeks and have kept the load off through the 56 weeks in the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of many active ingredient, which may make them more efficient and safer.

    Combo-pilling could be the newest fad or also the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that by right now there are no long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be authorized by the FDA.

    Seizures really are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure and heartbeat, and mustn't be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    An independent report published by Gant Daily in April also stated that naltrexone also works well with kleptomaniacs and gambling addicts, too. Citing research from your University of Minnesota School of Medicine, Gant Daily reported that this drug creates kleptomaniacs and chronic gamblers just as with alcohol and opioid addicts'by blocking the consequences of endorphins, which the brain releases when experiencing craving or compulsions.